CSNK1E
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Official Full Name
casein kinase 1, epsilon -
Overview
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
CSNK1E;casein kinase 1, epsilon;casein kinase I isoform epsilon;CKIE;CKIepsilon;HCKIE;CKI-epsilon;MGC10398
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Chicken
- Sf9 Insect Cell
- Mammalian Cell
- Insect Cell
- Wheat Germ
- E.coli
- HEK293
- Yeast
- Insect (sf21)
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
CSNK1E involved in several pathways and played different roles in them. We selected most pathways CSNK1E participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Canonical Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSNK1E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian Clock | RAI1,CRY1,DBP,CRY2,HELZ2,NRIP1,CPT1A,NAMPT,CARM1 |
| Cell Cycle, Mitotic | CSNK2B,KIF18A,CENPP,CDK11B,CDCA8,NEK9,KIF2B,LMNB1,SPC24,PANE1 |
| Assembly of the primary cilium | CEP97,CCT5,C11orf60,DCTN2,TTC26,DYNC1H1,B9D1,ODF2,B9D2,NPHP1 |
| Circadian rhythm | PRKAG2,SKP1,PER2,PRKAA1,FBXW11,NPAS2,NR1D1,RORA,PRKAG1,PRKAG3 |
| Canonical Wnt signaling pathway | DVL1,CSNK1A1,KLHL12,CSNK1D,DVL3,DVL2 |
| Anchoring of the basal body to the plasma membrane | CEP97,DCTN1A,CEP70,MAPRE1A,AKAP9,NINL,MKS1,DCTN2,IQCB1,SCLT1 |
| Centrosome maturation | CP110,CKAP5,NUMA1,CEP70,TUBG2,MAPRE1A,CLASP1A,FGFR1OP,NEDD1,TUBGCP3 |
| Cell cycle | POLD3,BLZF1,MASTL,HJURP,ORC5,ENSAA,DMC1,TRP53,OFD1,CEP78 |
Protein Function
CSNK1E has several biochemical functions, for example, ATP binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSNK1E itself. We selected most functions CSNK1E had, and list some proteins which have the same functions with CSNK1E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MAP3K12,EPHA8,RAD51L3,DAPK2A,DNAJA1,P2RX1,RPS6KC1,TSSK4,ABCC3,BAZ1B |
| protein serine/threonine kinase activity | PKN1,RAF1,MYO3B,LIMK1,ACVR2B,CDK14,SBK3,TNNI3K,PASK,GRK7A |
| protein kinase activity | PAK4,BMPR1BA,TEX14,CAMK1DB,SOX9,ADRBK1,SNRKA,CDC42BPB,NAT1,NPRL2 |
| poly(A) RNA binding | KRT18,RG9MTD1,ANXA7,POLR2B,ITM2B,STRAP,NCL,MRPL10,MBNL1,SRP14 |
| protein binding | SOD1,COMMD2,EEF1G,CYFIP1,LZTFL1,ZSCAN1,TAOK3,FCGR2C,CDK1,PSMD7 |
Interacting Protein
CSNK1E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSNK1E here. Most of them are supplied by our site. Hope this information will be useful for your research of CSNK1E.
MCC;APC;OCLN;AXIN1
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References
- Gonzalez-Sancho, JM; Greer, YE; et al. Functional Consequences of Wnt-induced Dishevelled 2 Phosphorylation in Canonical and Noncanonical Wnt Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 288:9428-9437(2013).
- Shanware, NP; Hutchinson, JA; et al. Casein Kinase 1-dependent Phosphorylation of Familial Advanced Sleep Phase Syndrome-associated Residues Controls PERIOD 2 Stability. JOURNAL OF BIOLOGICAL CHEMISTRY 286:-(2011).
