Recombinant Human CSE1L Over-expression Cell Lysate
Cat.No. : | CSE1L-9523HCL |
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- Gene Information
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Species : | Human |
Source : | HEK293 |
Tag : | DDK&Myc |
Description : | Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. |
Form : | 25mM Tris-HCl pH7.6, 150mM NaCl, 1% NP-40, 1mM EDTA, 1xProteinase inhibitor cocktail mix (Sigma), 1mM PMSF and 1mM Na3VO4 |
Molecular Mass : | 110.2 kDa |
Usage : | 1 vial of 100 µg gene specific transient over-expression cell lysate in RIPA buffer 1 vial of 100 µg empty vector transfected control cell lysate in RIPA buffer 1 vial of 250ul 2xSDS Sample Buffer (4% SDS, 125mM Tris-HCl pH6.8, 10% Glycerol, 0.002% Bromphenol blue, 100mM DTT) |
Storage : | Upon receiving, store the sample at -20 centigrade. Lysate samples are stable for 12 months from date of receipt when stored at -20 centigrade. Avoid repeated freeze-thaw cycles. Lysate samples can be diluted with 2xSDS Sample Buffer provided. After dilution, the protein sample should be aliquoted and stored at -20 centigrade for long term storage. Prior to SDS-PAGE fractionation, boil the lysate for 5 minutes. |
Gene Name | CSE1L CSE1 chromosome segregation 1-like (yeast) [ Homo sapiens ] |
Official Symbol | CSE1L |
Synonyms | CSE1L; CSE1 chromosome segregation 1-like (yeast); chromosome segregation 1 (yeast homolog) like; exportin-2; CAS; CSE1; XPO2; exp2; importin-alpha re-exporter; chromosome segregation 1-like protein; cellular apoptosis susceptibility protein; MGC117283; MGC130036; MGC130037; |
Gene ID | 1434 |
mRNA Refseq | NM_001316 |
Protein Refseq | NP_001307 |
MIM | 601342 |
UniProt ID | P55060 |
Chromosome Location | 20q13 |
Pathway | Direct p53 effectors, organism-specific biosystem; p53 pathway, organism-specific biosystem; |
Function | importin-alpha export receptor activity; protein binding; protein transporter activity; |
◆ Recombinant Proteins | ||
CSE1L-212HFL | Recombinant Full Length Human CSE1L Protein, C-Flag-tagged | +Inquiry |
CSE1L-9523HCL | Recombinant Human CSE1L Over-expression Cell Lysate | +Inquiry |
CSE1L-874R | Recombinant Rhesus Macaque CSE1L Protein, His (Fc)-Avi-tagged | +Inquiry |
CSE1L-9523H | Recombinant Human CSE1L protein, MYC/DDK-tagged | +Inquiry |
CSE1L-95HF | Recombinant Full Length Human CSE1L Protein | +Inquiry |
Not For Human Consumption!
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