Recombinant Human CRYM, His-tagged

• Cat.No.: CRYM-30256TH
• Product Overview: Recombinant full length Human mu Crystallin with N terminal His tag; 334 amino acids with tag, MWt 35.9kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1 amino acids
• Description: Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene.
• Conjugation: HIS
• Molecular Weight: 35.900kDa inclusive of tags
• Tissue specificity: Expressed in neural tissue, muscle and kidney.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSRVPAFLSA AEVEEHLRSS SLLIPPLETA LANFSSGPEG GVMQPVRTVV PVTKHRGYLG VMPAYSAAED ALTTKLVTFY EDRGITSVVP SHQATVLLFE PSNGTLLAVM DGNVITAKRT AAVSAIATKF LKPPSSEVLC ILGAGVQAYS HYEIFTEQFS FKEVRIWNRT KENAEKFADT VQGEVRVCSS VQEAVAGADV IITVTLATEP ILFGEWVKPG AHINAVGASR PDWRELDDEL MKEAVLYVDS QEAALKESGD VLLSGAEIFA ELGEVIKGVK PAHCEKTTVF KSLGMAVEDT VAAKLIYDSW SSGK
• Sequence Similarities: Belongs to the ornithine cyclodeaminase family.

Gene Information

• Gene Name: CRYM crystallin, mu [ Homo sapiens ]
• Official Symbol: CRYM
• Synonyms: CRYM; crystallin, mu; thiomorpholine-carboxylate dehydrogenase; DFNA40
• Gene ID: 1428
• mRNA Refseq: NM_001014444
• Protein Refseq: NP_001014444
• MIM: 123740
• Uniprot ID: Q14894
• Chromosome Location: 16p
• Function: NADP binding; oxidoreductase activity; protein homodimerization activity; thiomorpholine-carboxylate dehydrogenase activity; thyroid hormone binding