Recombinant Human CRYM, His-tagged

Specification
Gene Information
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Description :	Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene.
Protein length :	1 amino acids
Conjugation :	HIS
Molecular Weight :	35.900kDa inclusive of tags
Source :	E. coli
Tissue specificity :	Expressed in neural tissue, muscle and kidney.
Form :	Liquid
Purity :	>95% by SDS-PAGE
Storage buffer :	Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage :	Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids :	MGSSHHHHHH SSGLVPRGSH MSRVPAFLSA AEVEEHLRSS SLLIPPLETA LANFSSGPEG GVMQPVRTVV PVTKHRGYLG VMPAYSAAED ALTTKLVTFY EDRGITSVVP SHQATVLLFE PSNGTLLAVM DGNVITAKRT AAVSAIATKF LKPPSSEVLC ILGAGVQAYS HYEIFTEQFS FKEVRIWNRT KENAEKFADT VQGEVRVCSS VQEAVAGADV IITVTLATEP ILFGEWVKPG AHINAVGASR PDWRELDDEL MKEAVLYVDS QEAALKESGD VLLSGAEIFA ELGEVIKGVK PAHCEKTTVF KSLGMAVEDT VAAKLIYDSW SSGK
Sequence Similarities :	Belongs to the ornithine cyclodeaminase family.

Gene Name	CRYM crystallin, mu [ Homo sapiens ]
Official Symbol	CRYM
Synonyms	CRYM; crystallin, mu; thiomorpholine-carboxylate dehydrogenase; DFNA40;
Gene ID	1428
mRNA Refseq	NM_001014444
Protein Refseq	NP_001014444
MIM	123740
Uniprot ID	Q14894
Chromosome Location	16p
Function	NADP binding; oxidoreductase activity; protein homodimerization activity; thiomorpholine-carboxylate dehydrogenase activity; thyroid hormone binding;