Recombinant Human CRKL Protein, GST-tagged

• Cat.No.: CRKL-1889H
• Product Overview: Human CRKL full-length ORF ( NP_005198.1, 1 a.a. - 303 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 60.2 kDa
• AA Sequence: MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPDENE
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CRKL CRK like proto-oncogene, adaptor protein [ Homo sapiens (human) ]
• Official Symbol: CRKL
• Synonyms: CRKL; CRK like proto-oncogene, adaptor protein; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v crk avian sarcoma virus CT10 oncogene homolog like; crk-like protein
• Gene ID: 1399
• mRNA Refseq: NM_005207
• Protein Refseq: NP_005198
• MIM: 602007
• UniProt ID: P46109