Recombinant Human CREB1, GST-tagged

• Cat.No.: CREB1-162H
• Product Overview: Recombinant Human CREB Binding Protein bromodomain (1081-1197 aa) fused to a GST tag at the N-terminus

Specification

• Description: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The cAMP response element-binding protein (CREB) binding protein (CREBBP) bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53. This product contains the bromodomain region of CREBBP.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Liquid. 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
• Molecular Mass: 40.8 kDa (1081-1197 aa + NT GST Tag)
• Purity: ≥95%
• Storage: Store at -80°C. Avoid repeated freeze and thaw cycles. Stable for 1 year.
• Protein length: 1081-1197 a.a.

Gene Information

• Gene Name: CREB1 cAMP responsive element binding protein 1 [ Homo sapiens ]
• Official Symbol: CREB1
• Synonyms: CREB1; cAMP responsive element binding protein 1; cyclic AMP-responsive element-binding protein 1; CREB-1; transactivator protein; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; MGC9284
• Gene ID: 1385
• mRNA Refseq: NM_004379
• Protein Refseq: NP_004370
• MIM: 123810
• UniProt ID: P16220
• Chromosome Location: 2q34
• Pathway: AKT phosphorylates targets in the nucleus, organism-specific biosystem; ATF-2 transcription factor network, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Amphetamine addiction, organism-specific biosystem
• Function: RNA polymerase II activating transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; cAMP response element binding; double-stranded DNA binding; protein binding; protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; transcription cofactor activity; transcription factor binding