CREB1
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Official Full Name
cAMP responsive element binding protein 1 -
Overview
CREB (cAMP response element-binding) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. -
Synonyms
CREB1;cAMP responsive element binding protein 1provided;CREB;MGC9284;cyclic AMP-responsive element-binding protein 1;CREB-1;OTTHUMP00000163864;OTTHUMP00000163865;OTTHUMP00000206660;OTTHUMP00000206662;OTTHUMP00000206667;transactivator protein;active transcription factor CREB;cAMP-response element-binding protein-1;cAMP-responsive element-binding protein 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cell
- In Vitro Cell Free System
- Non
- His
- GST
- His&MBP
- His&Fc&Avi
Involved Pathway
CREB1 involved in several pathways and played different roles in them. We selected most pathways CREB1 participated on our site, such as AKT phosphorylates targets in the nucleus,AMPK signaling pathway,ATF-2 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling pathway | PRKAB2,Scd2,PPP2R1A,CPT1A,RAB14,SLC2A4,PIK3R3,PPP2R2D,PPARGC1A,INSR |
| Adaptive Immune System | PJA2,CD300E,CYBA,MAPKAP1,RACGAP1,SIGLEC11,KIF3A,FBXO17,CD300LH,CLTC |
| Activated TLR4 signalling | DHX9,AGER,CREB1B,CHST13,SAA1,PELI1,DUSP6,TICAM1,ALCAMB,DUSP4 |
| ATF-2 transcription factor network | CSRP2,KCNA3,JUN,JDP2,RUVBL2,DUSP10,CDK4,MAPK14,POU2F1,KAT5 |
| ATM Signaling Pathway | GADD45A |
| AKT phosphorylates targets in the nucleus | AKT3,CREB1B |
| Activation of NMDA receptor upon glutamate binding and postsynaptic events | CREB1B,ADCY1,AKAP9,CAMKK1B,NEFLB,ADCY3,NETO2,ADCY8,PDPK1A,DLG4 |
| Adipogenesis | DVL1,KLF6,GADD45A,HMGA1,E2F4,CFD,KLF6A,EGR2B,GDF10,BMP3 |
Protein Function
CREB1 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREB1 itself. We selected most functions CREB1 had, and list some proteins which have the same functions with CREB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cAMP response element binding | HMGA2,ATF6B,CREB3,CREB3L2,CREB3L3L,CREB3L3A,JUN,ATF6,CREB3L1,ATF2 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | TLE4,PROX1,GATA5,CIR1,THRA,SPI1,GATA6,USF2,NR5A2,SRF |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | KLF15,HOXC13,NRL,EGR1,MAFA,RELA,MYBL1,HOXC11,MEF2A,CTCFL |
| RNA polymerase II distal enhancer sequence-specific DNA binding | TFAP2C,TAL1,ZBTB16,GZF1,RXRB,H3F3A,JUN,MEOX2,ARID3B,SOX10 |
| enzyme binding | HIST1H2AN,PPP1R3B,UBE4B,NOTCH1,KMT2E,MLL5,DNM2,PAWR,MDM4,TAF10 |
| protein binding | ZNF625,PBX4,MAD1L1,MDH1,STK39,TFF3,PCID2,OTUD7B,NHP2,MARK4 |
| histone acetyltransferase binding | TP53,TAF7L,MEF2A,NR4A3,EID1,TRP53,EPAS1,HIF1A,KAT2B,SP1 |
| transcriptional activator activity, RNA polymerase II transcription factor binding | NR1H4,GBX2,NKX2,KLF14,NKX2-5,NFE2L1,SOX10,LMO2,JUN,MIXL1 |
| transcription factor activity, sequence-specific DNA binding | BACH2,ZNF649,ZFP42,TFAM,SOLH,ZRANB2,DEAF1,NANOG,TLX2,ZIC2 |
Interacting Protein
CREB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CREB1.
TSSK4;MEIS1;CREBBP;PASK;p03259-2
CREB1 Related Signal Pathway
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References
- Matsumura, H; Nakayama, Y; et al. Effects of interleukin-11 on the expression of human bone sialoprotein gene. JOURNAL OF BONE AND MINERAL METABOLISM 33:142-153(2015).
- Matsumura, H; Ogata, Y; et al. Melatonin regulates human bone sialoprotein gene transcription. JOURNAL OF ORAL SCIENCE 56:67-76(2014).
