Recombinant Human CPEB1 Protein (Cys311-Lys561), His tagged

• Cat.No.: CPEB1-2206H
• Product Overview: Recombinant human CPEB1 (Cys311-Lys561) fused with His tag was expressed in E. coli.

Specification

• Description: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 29.21 kDa
• Protein length: Cys311-Lys561
• Purity: >90% as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: CPEB1 cytoplasmic polyadenylation element binding protein 1 [ Homo sapiens (human) ]
• Official Symbol: CPEB1
• Synonyms: CPEB1; cytoplasmic polyadenylation element binding protein 1; cytoplasmic polyadenylation element-binding protein 1; CPEB; FLJ13203; h-CEBP; hCPEB-1; CPE-binding protein 1; CEBP; CPE-BP1; MGC34136; MGC60106
• Gene ID: 64506
• mRNA Refseq: NM_001079533
• Protein Refseq: NP_001073001
• MIM: 607342
• UniProt ID: Q9BZB8