CPEB1
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Official Full Name
cytoplasmic polyadenylation element binding protein 1 -
Overview
This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3 UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CPEB1;cytoplasmic polyadenylation element binding protein 1;cytoplasmic polyadenylation element-binding protein 1;CPEB;FLJ13203;CPE-binding protein 1;CPE-BP1;CPEB 1;CPEB1 protein;CPEB1_HUMAN;Cytoplasmic polyadenylation binding protein 1;Cytoplasmic polyadenylation element binding protein;h-CEBP;hCPEB-1;mKIAA0940;MKIAA0940 protein;CEBP
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&GST
- Non
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
CPEB1 involved in several pathways and played different roles in them. We selected most pathways CPEB1 participated on our site, such as Oocyte meiosis,Dorso-ventral axis formation,Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPEB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Progesterone-mediated oocyte maturation | AKT2L,IGF1,HSP90AA1.2,GNAIA,PDE3B,RAF1,MAPK12,CDC25A,PRKACBA,PIK3R2 |
| Dorso-ventral axis formation | NOTCH3,NOTCH1,NOTCH4,NOTCH2,CPEB1B,ETV6,SPIRE1A,PIWIL1,GRB2B,MAPK3 |
| Oocyte meiosis | PPP3CC,PPP2CA,SMC1A,CALM3B,PPP1CA,YWHAE,MAD2L2,CPEB1A,PLCZ1,YWHAG1 |
Protein Function
CPEB1 has several biochemical functions, for example, mRNA 3-UTR AU-rich region binding,mRNA 3-UTR binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPEB1 itself. We selected most functions CPEB1 had, and list some proteins which have the same functions with CPEB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | RABL2,PDPK1B,EGFRA,LEMD3,EEF1A1B,DHRS3,SEPT7A,RBPMS2A,CSF1RA,MYO10 |
| translation repressor activity, nucleic acid binding | CELF1,CPEB3,CPEB4,PURA,PPP1R2P9,PAIP2B,CPEB1A,CPEB2,CPEB1B,CELF4 |
| metal ion binding | HENMT1,ZDHHC8B,PPP3CB,DPYDB,ADCY3,GTF2E1,NFS1,PCXB,LHX1B,ATF7B |
| mRNA 3-UTR binding | LARP1,ELAVL4,PUM1,PUM2,IGF2BP1,SERBP1,PARN,CSDA,YBX2,RBM4 |
| ribosome binding | EFTUD1,MTRF1L,CPEB1A,NAA16,WIBG,CPEB1B,CPEB4,EIF5A,ETF1,ERI1 |
| translation factor activity, RNA binding | EIF4G2,CPEB3,ABCF1,EIF1,SOX11,EIF5,GTF2H2,MTIF3,GTF2H3,CPEB2 |
| mRNA 3-UTR AU-rich region binding | CPEB2,CPSF1,ELAVL1,CPEB1B,ZFP36,CPEB3 |
Interacting Protein
CPEB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPEB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPEB1.
SLC16A7
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