Recombinant Human Corticotropin Releasing Hormone, T7-tagged

• Cat.No.: CRH-3048H
• Product Overview: Recombinant Human CRH was produced inE.coliwith a T7 tag at N-terminus. MW = 21422 Da (27-196 aa).

Specification

• Cat. No.: CRH-3048H
• Description: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
• Source: E.coli.
• Form: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.
• Purity: 95%.
• Applications: MS. SDS.
• Protein length: 27-196 a.a.

Gene Information

• Gene Name: CRH corticotropin releasing hormone [ Homo sapiens ]
• Synonyms: CRH; corticotropin releasing hormone; CRF; corticoliberin; corticotropin-releasing factor; Corticotropin-releasing hormone
• Gene ID: 1392
• mRNA Refseq: NM_000756
• Protein Refseq: NP_000747
• MIM: 122560
• UniProt ID: P06850
• Chromosome Location: 8q13
• Pathway: Long-term depression; Neuroactive ligand-receptor interaction
• Function: adrenocorticotropin-releasing hormone activity; corticotropin-releasing hormone receptor 1 binding; corticotropin-releasing hormone receptor 2 binding; hormone activity; neuropeptide hormone activity; receptor binding