Recombinant Human COQ6 Protein, His-tagged

• Cat.No.: COQ6-493H
• Product Overview: Recombinant Human COQ6, transcript variant 1, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The protein encoded by tHis gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of tHis gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in tHis gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for tHis gene.
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 50.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: COQ6 coenzyme Q6, monooxygenase [ Homo sapiens (human) ]
• Official Symbol: COQ6
• Synonyms: CGI10; CGI-10; COQ10D6; COQ6
• Gene ID: 51004
• mRNA Refseq: NM_182476
• Protein Refseq: NP_872282
• MIM: 614647
• UniProt ID: Q9Y2Z9