Recombinant Human Complement Component 3a

• Cat.No.: C3a-44H
• Product Overview: Recombinant Human Complement Component 3a was produced from yeast.

Specification

• Species: Human
• Source: Yeast
• Tag: Non
• Description: C3a is a one of the proteins formed by the cleavage of complement component 3; the other is C3b.C3a plays an important role in chemotaxis, though not as important a role as C5a.It is also an anaphylatoxin.Soluble C3-convertase, also known as C4b2a, catalyzes the proteolytic cleavage of C3 into C3a and C3b as part of the classical complement system as well as the mannan-binding lectin pathway. C3a is an anaphylotoxin, and C3b serves as an opsonizing agent. Factor I can cleave C3b into C3c and C3d, the latter of which plays a role in enhancing B cell responses. Complement Component 3a (C3a) is an essential regulatory factor and inhibiting its binding to a C3a receptor will diminish the inflammation response by disrupting the cascade. We report the design, synthesis, in vitro and in vivo activity of diiminoisoindolines as C3a antagonists.
• Form: Lyophilized from sterile 20mM PB,240mM NaCl,PH6.0.
• Molecular Mass: 41.1kDa
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >95 % as determined by SDS-PAGE
• Applications: Western blotting, ELISA
• Storage: Store it under sterile conditions at -20℃ to -97℃ upon receiving.Recommend to aliquot the protein into smaller quantities for optimal storage.