Recombinant Human COMP, His-tagged

• Cat.No.: COMP-3658H
• Product Overview: Total 783 AA. MW: 85.75 kDa (calculated). C-Terminal His-tag+myc-epitope.

Specification

• Species: Human
• Source: CHO
• Tag: His
• Description: Cartilage oligomeric matrix protein is a protein that in humans is encoded by the COMP gene. The protein encoded by this gene is a noncollagenous extracellular matrix protein. It consists of five identical glycoprotein subunits. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. COMP is a marker of cartilage turnover.
• Form: Frozen in production medium.
• Research topic: Bone and cartilage metabolism
• Reconstitution: Defrost at ambient temperature.
• Applications: Drug discovery; In vitro diagnostic
• Quality Control Test: SDS-PAGE; ELISA test
• Sequences of amino acids: AAQPARRAVR SFCVLLLTLA ALGASGQGQS PLGSDLGPQM LRELQETNAA LQDVRELLRQ QVREITFLKN TVMECDACGM QQSVRTGLPS VRPLLHCAPG FCFPGVACIQ TESGARCGPC PAGFTGNGSH CTDVNECNAH PCFPRVRCIN TSPGFRCEAC PPGYSGPTHQ GVGLAFAKAN KQVCTDINEC ETGQHNCVPN SVCINTRGSF QCGPCQPGFV GDQASGCQRR AQRFCPDGSP SECHEHADCV LERDGSRSCV CAVGWAGNGI LCGRDTDLDG FPDEKLRCPE RQCRKDNCVT VPNSGQEDVD RDGIGDACDP DADGDGVPNE KDNCPLVRNP DQRNTDEDKW GDACDNCRSQ KNDDQKDTDQ DGRGDACDDD IDGDRIRNQA DNCPRVPNSD QKDSDGDGIG DACDNCPQKS NPDQADVDHD FVGDACDSDQ DQDGDGHQDS RDNCPTVPNS AQEDSDHDGQ GDACDDDDDN DGVPDSRDNC RLVPNPGQED ADRDGVGDVC QDDFDADKVV DKIDVCPENA EVTLTDFRAF QTVVLDPEGD AQIDPNWVVL NQGREIVQTM NSDPGLAVGY TAFNGVDFEG TFHVNTVTDD DYAGFIFGYQ DSSSFYVVMW KQMEQTYWQA NPFRAVAEPG IQLKAVKSST GPGEQLRNAL WHTGDTESQV RLLWKDPRNV GWKDKKSYRW FLQHRPQVGY IRVRFYEGPE LVADSNVVLD TTMRGGRLGV FCFSQENIIW ANLRYRCNDT IPEDYETARG GPEQKLISEE DLNSAVDHHH HHH
• Storage: Store frozen at -20°C. Stable until expiry date.
• Pathways: ECM-receptor interaction; Focal Adhesion; Focal adhesion; Malaria; Phagosome; TGF-beta signaling pathway

Gene Information

• Gene Name: COMP cartilage oligomeric matrix protein [ Homo sapiens ]
• Official Symbol: COMP
• Synonyms: COMP; cartilage oligomeric matrix protein; MED; EDM1; EPD1; PSACH; THBS5; MGC131819; MGC149768; cartilage oligomeric matrix protein; TSP5; thrombospondin-5; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple); Cartilage oligomeric matrix protein; Thrombospondin-5
• Gene ID: 1311
• mRNA Refseq: NM_000095
• Protein Refseq: NP_000086
• MIM: 600310
• UniProt ID: P49747
• Chromosome Location: 19p13.1
• Function: calcium ion binding; collagen binding; extracellular matrix structural constituent; heparan sulfate proteoglycan binding; heparin binding; protein binding