Recombinant Human COL4A3BP, His-tagged

• Cat.No.: COL4A3BP-27223TH
• Product Overview: Recombinant fusion protein (Human) with His-Tag at N-terminus.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene.
• Conjugation: HIS
• Tissue specificity: Widely expressed.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: 0.002% Sodium Azide, 2.5mM ImidazoleConstituents: 3mM Sodium chloride, 10mM Tris, pH 8
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 1 PH domain.Contains 1 START domain.

Gene Information

• Gene Name: COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein [ Homo sapiens ]
• Official Symbol: COL4A3BP
• Synonyms: COL4A3BP; collagen, type IV, alpha 3 (Goodpasture antigen) binding protein; collagen type IV alpha-3-binding protein; ceramide transporter; CERT; GPBP; StAR related lipid transfer (START) domain containing 11; STARD11
• Gene ID: 10087
• mRNA Refseq: NM_001130105
• Protein Refseq: NP_001123577
• MIM: 604677
• Uniprot ID: Q9Y5P4
• Chromosome Location: 5q13.3
• Pathway: Metabolism of lipids and lipoproteins, organism-specific biosystem; Sphingolipid metabolism, organism-specific biosystem
• Function: ceramide binding; phosphatidylinositol-4-phosphate binding; protein binding; protein kinase activity