Recombinant Human COL1A2, His-tagged

• Cat.No.: COL1A2-116H
• Product Overview: Recombinant Human COL1A2 was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose.

Specification

• Description: This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1017-1366aa
• Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freezethaw cycles should be avoided.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: COL1A2?collagen, type I, alpha 2 [?Homo sapiens?(human) ]
• Official Symbol: COL1A2
• Synonyms: COL1A2; OI4; collagen, type I, alpha 2; collagen alpha-2(I) chain; type I procollagen; alpha 2(I)-collagen; alpha-2 type I collagen; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-2 chain
• Gene ID: 1278
• mRNA Refseq: NM_000089
• Protein Refseq: NP_000080
• MIM: 120160
• UniProt ID: P08123
• Chromosome Location: 7q22.1
• Pathway: Binding and Uptake of Ligands by Scavenger Receptors; ECM-receptor interaction; Focal Adhesion
• Function: extracellular matrix structural constituent; identical protein binding; metal ion binding