COL1A2
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Official Full Name
collagen, type I, alpha 2 -
Overview
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2;chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis;and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type;VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms;associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1;chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three;transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. -
Synonyms
COL1A2;collagen, type I, alpha 2;OI4, osteogenesis imperfecta type IV;collagen alpha-2(I) chain;alpha 2(I) collagen;alpha 2 collagen type I;collagen I;alpha 2 polypeptide;collagen of skin;tendon and bone;alpha 2 chain;type I procollagen;alpha
Recombinant Proteins
- Human
- Rat
- Dog
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- His
- GST
- Avi
- Fc
Involved Pathway
COL1A2 involved in several pathways and played different roles in them. We selected most pathways COL1A2 participated on our site, such as Amoebiasis,Assembly of collagen fibrils and other multimeric structures,Binding and Uptake of Ligands by Scavenger Receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endothelins | EDNRB,EDN1,EDN3,EDNRA,COL3A1,CYSLTR1,EDN2 |
| Binding and Uptake of Ligands by Scavenger Receptors | CD163,IGLC2,Alb,APOA1B,SPARC,SAA1,HPX,NFX1,COL3A1,SCGB3A2 |
| Assembly of collagen fibrils and other multimeric structures | PCOLCE,COL8A1,COL10A1A,COL4A3,COL6A1,LOXL2,COL6A3,LOXL1,COL4A5,COL11A1B |
| Collagen formation | LOXL3,COL9A1A,PPIB,COL17A1,COL5A3B,EMID2,COL8A1A,COL6A3,PCOLCEB,SERPINH1 |
| Amoebiasis | TGFB1,PIK3CD,SERPINB9,PLCB2,LAMA3,COL5A2,ARG2,IL-8,CSF2,SERPINB13 |
| Collagen biosynthesis and modifying enzymes | BMP1B,COL4A6,COL4A4,BMP1A,COL6A3,COL6A1,COL28A1,EMID2,SERPINH1B,PCOLCE2 |
| ECM-receptor interaction | ITGB4,ITGA1,LAMB2,COL4A4,COL27A1,ITGB5,CD36,COL4A1,SV2B,VTN |
| C-MYB transcription factor network | TRIM28,CEBPA,SKI,MYB,YEATS4,ELANE,ADORA2B,SLC25A3,LECT2,SMARCA2 |
Protein Function
COL1A2 has several biochemical functions, for example, SMAD binding,extracellular matrix structural constituent,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL1A2 itself. We selected most functions COL1A2 had, and list some proteins which have the same functions with COL1A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | DNM1L,TRAF6,S100A1,ALS2CL,SERPINA1D,RPE,MDM2,MPST,CRYBB2,GRIK5 |
| metal ion binding | ZBTB2,TRAF4B,MYO9B,CMTM2A,PDSS1,ANTXR2A,PCXB,THAP8,EXT2,ZFP42 |
| protein binding | TMEM88,SYT11,MKI67,ATRIP,FRS2,CACNA1SB,CYFIP1,POU2AF1,FGFR1OP2,SCUBE3 |
| extracellular matrix structural constituent | LAMB1,COL5A2,KAL1,PXDN,CD4,LAMA1,IMPG1,COL1A1,COL11A1B,OPTC |
| SMAD binding | BMPR1B,PRDM16,COL3A1,SKOR1A,SKOR1B,ACVR1,SMURF2,DAB2,SMAD2,SKI |
| platelet-derived growth factor binding | COL5A1,PDGFA,COL4A1,Pdgfa&Pdgfb,COL1A1,COL6A1,COL3A1,PDGFRA,COL2A1,PDGFB |
| protein binding, bridging | BCL3,FGG,PPP2R3A,FSCN1A,CAV1,MEN1,CNKSR1,STUB1,FLRT2,FBXW7 |
Interacting Protein
COL1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL1A2.
SGTA;UBQLN1;UBQLN1;ITGA2;q69hr1_cioin;q5yb85_strsg;TFAP2A;ZNF16;LOX;gltX;hemL2;TFAP2C;ZWINT;RAB5A
Resources
Research Area
Angiogenesis InhibitorChondrogenesis Markers
Other Secreted VSMC Molecules
Osteogenesis Markers
Extracellular Matrix Molecules
Osteoprogenitor Markers
Angiogenesis Inhibitor in Cancer
Collagens
Related Services
Related Products
References
- Jacobsen, CM; Barber, LA; et al. Targeting the LRP5 Pathway Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta. JOURNAL OF BONE AND MINERAL RESEARCH 29:2297-2306(2014).
- Grafel, I; Yang, T; et al. Excessive transforming growth factor-beta signaling is a common mechanism in osteogenesis imperfecta. NATURE MEDICINE 20:670-675(2014).
