Recombinant Human CLP1 Protein, GST-tagged

• Cat.No.: CLP1-4667H
• Product Overview: Human HEAB full-length ORF ( NP_006822.1, 1 a.a. - 425 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: GST
• Description: This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
• Molecular Mass: 74 kDa
• AA Sequence: MGEEANDDKKPTTKFELERETELRFEVEASQSVQLELLTGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSVQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGSGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDLEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CLP1 cleavage and polyadenylation factor I subunit 1 [ Homo sapiens (human) ]
• Official Symbol: CLP1
• Synonyms: CLP1; cleavage and polyadenylation factor I subunit 1; HEAB; hClp1; polyribonucleotide 5'-hydroxyl-kinase Clp1; ATP/GTP-binding protein; homolog of yeast CFIA subunit Clp1p; polyadenylation factor Clp1; polynucleotide kinase Clp1; pre-mRNA cleavage complex II protein Clp1; EC 2.7.1.78
• Gene ID: 10978
• mRNA Refseq: NM_001142597
• Protein Refseq: NP_001136069
• MIM: 608757
• UniProt ID: Q92989