Recombinant Human CLEC10A protein, Fc-tagged

• Cat.No.: CLEC10A-348H
• Product Overview: Recombinant Human CLEC10A protein (Gln61-His316), fused to human IgG1 Fc tag at N-terminus, was expressed in human 293 cells (HEK293).

Specification

• Description: C-type lectin domain family 10 member A (CLEC10A) is also known as C-type lectin superfamily member 14 (CLECSF14), Macrophage lectin 2, CD antigen CD301. CLEC10A/CD301 is a unique calcium-type (C-type) lectin, which expressed on Dendritic cells (DCs). CLEC10A/CD301 probable role in regulating adaptive and innate immune responses. CLEC10A/CD301 binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine (GalNAc), linked to serine or threonine. There are two homologues in mice: MGL1 and MGL2 (CD301a and CD301b).
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 55.7 kDa. The protein migrates as 60-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Protein length: 256
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Purity: >92% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 centigrade to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: CLEC10A
• Official Symbol: CLEC10A
• Synonyms: CLEC10A; C-type lectin domain family 10, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 14 (macrophage derived) , CLECSF13, CLECSF14; C-type lectin domain family 10 member A; CD301; HML; HML2; macrophage lectin 2 (calcium dependent); C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 13 (macrophage-derived); C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 14 (macrophage-derived); MGL; CLECSF13; CLECSF14
• Gene ID: 10462
• mRNA Refseq: NM_006344
• Protein Refseq: NP_006335
• MIM: 605999
• UniProt ID: Q8IUN9