Cat. No. :	CLCF1-3626H
Description :	CLCF1, also known as cardiotrophin-like cytokine factor 1, belongs to the interleukin 6 family of cytokines, which are involved in cell signaling through phosphorylation of gp130. CLCF1 has a sequence of 225-amino acids with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine.
Form :	Liquid. 20mM sodium citrate (pH 3.5), 0.4M Urea, 10% glycerol
Molecular Weight :	24.6 kDa (219aa)
Purity :	> 90% by SDS - PAGE
Concentration :	1 mg/ml (determined by Bradford assay)
Sequences of amino acids :	MGSSHHHHHH SSGLVPRGSH MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF
Storage :	Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways :	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway

Gene Name	CLCF1 cardiotrophin-like cytokine factor 1 [ Homo sapiens ]
Official Symbol	CLCF1
Synonyms	CLCF1; cardiotrophin-like cytokine factor 1; CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1; novel neurotrophin-1; B-cell stimulating factor 3; B-cell stimulatory factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; B cell-stimulating factor 3; cold-induced sweating syndrome 2
Gene ID	23529
mRNA Refseq	NM_001166212
Protein Refseq	NP_001159684
MIM	607672
UniProt ID	Q9UBD9
Chromosome Location	11q13.3
Function	cytokine activity; growth factor activity