Recombinant Human CITED2, His-tagged

• Cat.No.: CITED2-1353H
• Product Overview: Recombinant Human CITED2 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 278 amino acids (1-270 a.a.) and having a molecular mass of 29.5 kDa. The CITED2 is fused to 8 amino acids His Tag at C-terminus and purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-270 a.a.
• Description: CITED2 is a significant transcriptional cofactor that takes part in multiple organ development. CITED2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a negative regulator for HIF1A through its competitive binding with HIF1A to CBP/p300. CITED2 is essential for mouse fetal liver hematopoiesis and is necessary for the appropriate formation of the hyaloid vasculature and for lens morphogenesis. CITED2 is a coactivator of HNF4alpha and necessary for liver development. CITED2 is a coactivator of PPAR-alpha and both participate in signaling cascades of hypoxic response and angiogenesis.
• Amino Acid Sequence: MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG PPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG SSSGGGAGSS NSGGGSGSGN MPASVAHVPA AMLPPNVIDT DFIDEEVLMS LVIEMGLDRI KELPELWLGQ NEFDFMTDFV CKQQPSRVSC LEHHHHHH.
• Physical Appearance: Sterile Filtered colorless solution.
• Formulation: The CITED2 solution contains 20mM Tris pH-8, 1mM DTT, 0.1M NaCl & 40% glycerol.
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Stability: CITED2 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 [ Homo sapiens ]
• Synonyms: CITED2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; MRG1; P35SRJ; MSG-related protein 1; P35srj; Cbp/p300-interacting transactivator 2
• Gene ID: 10370
• mRNA Refseq: NM_006079
• Protein Refseq: NP_006070
• MIM: 602937
• UniProt ID: Q99967
• Chromosome Location: 6q23.3
• Function: protein binding; transcription coactivator activity; transcription factor activity