Recombinant Human cIAP1, GST-tagged

• Cat.No.: cIAP1-11240H
• Product Overview: Recombinant Human cIAP1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-350a.a.
• Description: The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: BIRC2 baculoviral IAP repeat containing 2 [ Homo sapiens ]
• Official Symbol: BIRC2
• Synonyms: BIRC2; baculoviral IAP repeat containing 2; API1, baculoviral IAP repeat containing 2; baculoviral IAP repeat-containing protein 2; apoptosis inhibitor 1; c IAP1; cIAP1; hiap 2; MIHB; NFR2 TRAF signalling complex protein; RNF48; IAP-2; IAP homolog B; RING finger protein 48; inhibitor of apoptosis protein 2; baculoviral IAP repeat-containing 2; NFR2-TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 2; API1; HIAP2; Hiap-2; c-IAP1
• Gene ID: 329
• mRNA Refseq: NM_001166
• Protein Refseq: NP_001157
• MIM: 601712
• UniProt ID: Q13490
• Chromosome Location: 11q22
• Pathway: Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem
• Function: metal ion binding; protein N-terminus binding; protein binding; transcription coactivator activity; ubiquitin-protein ligase activity; zinc ion binding