Recombinant Human CHMP1A, His-tagged

• Cat.No.: CHMP1A-7059H
• Product Overview: Recombinant human CHMP1A protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: Charged multivesicular body protein 1a, also known as CHMP1A, belongs to the vacuolar sorting protein family and functions as chromatin-modifying protein. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), as well as required for the formation of these bodies. The MVBs pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. CHMP1 interacts with VPS4B and localizes to early endosomes. Two isoforms, encoded by distinct genes, exists for CHMP1. They are designated CHMP1A and CHMP1B.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl,20% glycerol,1mM DTT
• Molecular Mass: 24.1 kDa (219aa)
• Protein length: 1-196aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMDDTLFQ LKFTAKQLEK LAKKAEKDSK AEQAKVKKAL LQKNVECARV YAENAIRKKN EGVNWLRMASRVDAVASKVQ TAVTMKGVTK NMAQVTKALD KALSTMDLQK VSSVMDRFEQ QVQNLDVHTS VMEDSMSSAT TLTTPQEQVD SLIMQIAEEN GLEVLDQLSQ LPEGASAVGE SSVRSQEDQL SRRLAALRN
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: CHMP1A charged multivesicular body protein 1A [ Homo sapiens ]
• Official Symbol: CHMP1A
• Synonyms: CHMP1A; charged multivesicular body protein 1A; chromatin modifying protein 1A , PCOLN3, procollagen (type III) N endopeptidase , PRSM1; charged multivesicular body protein 1a; CHMP1; KIAA0047; Vps46A; protease, metallo, 1, 33kD; chromatin modifying protein 1A; procollagen (type III) N-endopeptidase; vacuolar protein sorting-associated protein 46-1; charged multivesicular body protein 1/chromatin modifying protein 1; PRSM1; PCOLN3; VPS46A; VPS46-1
• Gene ID: 5119
• mRNA Refseq: NM_001083314
• Protein Refseq: NP_001076783
• MIM: 164010
• UniProt ID: Q9HD42
• Chromosome Location: 16q24.3
• Function: metallopeptidase activity; protein binding; protein domain specific binding; zinc ion binding