Recombinant Human CHI3L1 Protein (Asn112-Lys377), His tagged

Specification
Gene Information
Related Products
Download

Description :	Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
Source :	E. coli
Species :	Human
Tag :	His
Form :	Lyophilized powder/frozen liquid
Molecular Mass :	29.96 kDa
Protein length :	Asn112-Lys377
Purity :	>90% as determined by SDS-PAGE
Notes :	For research use only.
Storage :	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
Storage Buffer :	Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
Reconstitution :	Reconstitute in sterile water for a stock solution.
Shipping :	They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Name	CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) [ Homo sapiens (human) ]
Official Symbol	CHI3L1
Synonyms	CHI3L1; chitinase 3-like 1 (cartilage glycoprotein-39); chitinase-3-like protein 1; GP39; YKL40; 39 kDa synovial protein; cartilage glycoprotein 39; ASRT7; GP-39; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39; FLJ38139; DKFZp686N19119;
Gene ID	1116
mRNA Refseq	NM_001276
Protein Refseq	NP_001267
MIM	601525
UniProt ID	P36222