Recombinant Human Chemokine (C-C motif) Ligand 3

• Cat.No.: CCL3-363H
• Product Overview: Recombinant humanCCL3 contains 69 amino acid residues was expessed in Inscet cells. Itsmolecular weight is 7700 Dalton.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Non
• Description: CCL3 is identical toMIP1-beta (ACT II isotype) except for two amino acid substitutions: argininefor histidine at position 22 and serine for glycine at position 47 of themature protein.
• Form: Lyophilized withoutadditives
• Molecular Weight: 7.7 kDa
• Purity: > 98% asdetermined by SDS-PAGE analysis
• Endotoxin Level: < 0.1 ng/µg ofLAG1
• Biological Activity: Determined by itsability to chemoattract CCR5 transfected cells using a concentration of0.1-10.0 ng/ml.
• Reconstitution: Centrifugevial prior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions.
• Storage: Store lyophilizedprotein at -20°C to -80°C and reconstituted protein in working aliquots at-20°C to -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: CCL3

Gene Information

• Gene Name: CCL3 chemokine (C-C motif) ligand 22 [Homo sapiens ]
• Synonyms: CCL3; chemokine (C-Cmotif) ligand 3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha; LD78 alphabeta; small inducible cytokine A3 (homologous to mouse Mip-1a); SIS-beta;G0/G1 switch regulatory protein 19-1; G0S19-1 protein; LD78 alpha beta;Macrophage inflammatory protein 1-alpha; PAT 464.1; Small-inducible cytokineA3; Tonsillar lymphocyte LD78 alpha protein; C-C motif chemokine 3;Small-inducible cytokine A3; MIP-1-alpha; Tonsillar lymphocyte LD78 alphaprotein; G0/G1 switch regulatory protein 19-1; G0S19-1 protein; SIS-beta; PAT464.1
• Gene ID: 6348
• mRNA Refseq: NM_002983
• Protein Refseq: NP_002974
• MIM: 182283
• UniProt ID: P10147
• Chromosome Location: 17q11-q21
• Pathway: Chemokine signalingpathway; Cytokine-cytokine receptor interaction; Chagas disease (Americantrypanosomiasis); Chemokine receptors bind chemokines; Class A/1(Rhodopsin-like receptors); GPCR ligand binding; IL12-mediated signalingevents; Peptide ligand-binding receptors; Rheumatoid arthritis; Senescenceand Autophagy; Salmonella infection; Signal Transduction; Signaling by GPCR;Toll-like receptor signaling pathway
• Function: chemoattractantactivity; chemokine activity; signal transducer activity