Recombinant Human CENPM, His-tagged

• Cat.No.: CENPM-11099H
• Product Overview: Recombinant Human CENPM protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-180a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: CENPM centromere protein M [ Homo sapiens ]
• Official Symbol: CENPM
• Synonyms: CENPM; centromere protein M; C22orf18, chromosome 22 open reading frame 18; CENP M; MGC861; Pane1; interphase centromere complex protein 39; proliferation associated nuclear element 1; proliferation-associated nuclear element protein 1; PANE1; CENP-M; C22orf18; bK250D10.2
• Gene ID: 79019
• mRNA Refseq: NM_001002876
• Protein Refseq: NP_001002876
• MIM: 610152
• UniProt ID: Q9NSP4
• Chromosome Location: 22q13.2
• Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; M Phase, organism-specific biosystem; Mitotic M-M/G1 phases, organism-specific biosystem; Mitotic Prometaphase, organism-specific biosystem