Recombinant Human CENPI Protein, His-tagged

• Cat.No.: CENPI-276H
• Product Overview: Recombinant Human CENPI(Leu292~Gly528) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 31.1kDa
• Identity: Reconstitute in PBS or others
• Protein length: Leu292~Gly528
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: CENPI centromere protein I [ Homo sapiens ]
• Official Symbol: CENPI
• Synonyms: CENPI; centromere protein I; FSH primary response (LRPR1 homolog, rat) 1 , FSH primary response (LRPR1, rat) homolog 1 , FSHPRH1; CENP I; LRPR1; Mis6; FSH primary response 1; FSH primary response protein 1; leucine-rich primary response protein 1; interphase centromere complex protein 19; follicle-stimulating hormone primary response protein; CENP-I; FSHPRH1
• Gene ID: 2491
• mRNA Refseq: NM_006733
• Protein Refseq: NP_006724
• MIM: 300065
• UniProt ID: Q92674