Recombinant Human CDKN1A Protein (Met1-Pro164), His tagged
Cat.No. : | CDKN1A-1075H |
Product Overview : | Recombinant human CDKN1A (Met1-Pro164) fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
- Download
Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | Met1-Pro164 |
Description : | May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding. Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest. |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 20.16 kDa |
Purity : | >90% as determined by SDS-PAGE. |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name | CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) [ Homo sapiens (human) ] |
Official Symbol | CDKN1A |
Synonyms | CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); CDKN1; cyclin-dependent kinase inhibitor 1; CAP20; CIP1; P21; p21CIP1; p21Cip1/Waf1; SDI1; WAF1; DNA synthesis inhibitor; CDK-interacting protein 1; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6; MDA-6; |
Gene ID | 1026 |
mRNA Refseq | NM_000389 |
Protein Refseq | NP_000380 |
MIM | 116899 |
UniProt ID | P38936 |
◆ Recombinant Proteins | ||
Cdkn1a-1251R | Recombinant Rat Cdkn1a protein, His & T7-tagged | +Inquiry |
CDKN1A-619R | Recombinant Rhesus Macaque CDKN1A Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD14B-9238H | Recombinant Human ABHD14B protein, His-tagged | +Inquiry |
CDKN1A-045H | Recombinant Human CDKN1A Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
CDKN1A-1075H | Recombinant Human CDKN1A Protein (Met1-Pro164), His tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
CDKN1A-7618HCL | Recombinant Human CDKN1A 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All CDKN1A Products
Required fields are marked with *
My Review for All CDKN1A Products
Required fields are marked with *
0
Inquiry Basket