CDKN1A
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Official Full Name
cyclin-dependent kinase inhibitor 1A (p21, Cip1) -
Overview
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010] -
Synonyms
CDKN1A;cyclin-dependent kinase inhibitor 1A (p21, Cip1);P21;CIP1;SDI1;WAF1;CAP20;CDKN1;MDA-6;p21CIP1;cyclin-dependent kinase inhibitor 1;DNA synthesis inhibitor;CDK-interacting protein 1;CDK-interaction protein 1;wild-type p53-activated fragment 1;melanoma differentiation associated protein 6
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Zebrafish
- Rhesus macaque
- E. coli
- Wheat Germ
- E.coli
- Mammalian Cell
- HEK293
- Mouse
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- N-His
- GST
- His
- His&T7
- Non
- His&MBP
- N-GST
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
CDKN1A involved in several pathways and played different roles in them. We selected most pathways CDKN1A participated on our site, such as AKT phosphorylates targets in the cytosol,AMPK signaling,Adaptive Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AhR pathway | CYP1A1,NQO1,CYP1A2,FLG,AHRR,AHR,AIP,JUND,CDC37,PTGES3 |
| Adipogenesis | FOXC2,CTNNB1,HMGA1,NRIP1,CEBPB,CELF1,DVL1,MEF2AA,PIANP,NAMPT |
| Adaptive Immune System | CYBA,NRG4,CLEC2D,CD300C,RNF138,TRIM11,SPTBN2,LRSAM1,KLRG1,ICAM4 |
| Androgen receptor signaling pathway | RUNX2A,RNF4,RNF6,CREBBP,HMGB2A,HTATIP,DAXX,CTNNB2,SMARCE1,CCDC102A |
| Alpha6-Beta4 Integrin Signaling Pathway | MST1R,CD151L,PLEC,DST,EIF4EB,EIF4EBP1,EIF4E,COL17A1,NTN1A,DSP |
| AMPK signaling | CPT1C,CPT1B,CAMKK2,ELAVL1,ADRA1B,SLC2A4RG,PPARGC1B,EEF2,LOC729991,ADRa1A |
| Angiopoietin receptor Tie2-mediated signaling | ELF2,GRB7,ELF1,BMX,AGTR1,GRB14,DOK2,CRK |
| AKT phosphorylates targets in the cytosol | CDKN1B,CHUK,AKT3 |
Protein Function
CDKN1A has several biochemical functions, for example, cyclin binding,cyclin-dependent protein kinase activating kinase activity,cyclin-dependent protein serine/threonine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN1A itself. We selected most functions CDKN1A had, and list some proteins which have the same functions with CDKN1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | COPS4,MBD3,MEOX2,CNOT1,MMP20,CCDC123,TROAP,USHBP1,RGS14,ACVR1 |
| protein complex binding | KRIT1,PPP2R2A,SKIL,NSF,UFD1L,CAPG,HADHA,NDUFA8,ITPR1,TULP2 |
| cyclin-dependent protein kinase activating kinase activity | ALPK2 |
| cyclin binding | PTCH1,CUL3,INCA1,CDK5RAP3,MDFIC,USP2,CDK14,CDK13,FBXW7,PFTK1 |
| ubiquitin protein ligase binding | RFFL,CDC34B,RIPK1,FANCL,GSK3B,DNAJA1,SLC25A5,TRIM28,MC1R,SUMO2 |
| cyclin-dependent protein serine/threonine kinase inhibitor activity | CDKN1D,CDKN1C,CDKN2D,INCA1,HEXIM2,CDKN1BB,CDKN2C,HEXIM1,Casp3,CDKN1B |
| metal ion binding | RAB11FIP4A,TIMP4,TRIM35-30,ADSSL,NR1D1,ZFP39,ZFP27,KLF2A,ZRANB1B,ADNP2 |
Interacting Protein
CDKN1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN1A.
CDK2;PCNA
CDKN1A Related Signal Pathway
Resources
Research Area
Tumor SuppressorsPhospholipases, Small GTPases, and Other Molecules in the Akt Pathway
DNA Damage and Repair
Melanoma Biomarkers
G1 (Restriction) Checkpoints
CKIs(Cyclin Dependent Kinase Inhibitors)
Related Services
Related Products
References
- Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
- Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
