Recombinant Human CDKL3, GST-tagged

• Cat.No.: CDKL3-148H
• Product Overview: Recombinant full-length human CDKL3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: CDKL3 or cyclin-dependent kinase-like 3 is a member of cyclin-dependent protein kinase (CDK) family which is highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and is known to be important regulators of cell cycle progression and cellular proliferation. CDKL3 is a novel CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases. CDKL3 is identified as a gene absent in leukemic patients with chromosome 5q deletion and this loss may be an important determinant of dysmyelopoiesis.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~98 kDa
• Purity: >70% by densitometry
• Applications: Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μl

Gene Information

• Gene Name: CDKL3 cyclin-dependent kinase-like 3 [ Homo sapiens ]
• Official Symbol: CDKL3
• Synonyms: CDKL3; cyclin-dependent kinase-like 3; NKIAMRE; serine threonine protein kinase NKIAMRE; serine-threonine protein kinase NKIAMRE; serine/threonine-protein kinase NKIAMRE
• Gene ID: 51265
• mRNA Refseq: NM_001113575
• Protein Refseq: NP_001107047
• MIM: 608459
• UniProt ID: Q8IVW4
• Chromosome Location: 5q31
• Function: ATP binding; cyclin-dependent protein kinase activity; nucleotide binding; protein kinase activity