Recombinant Human CDK8, MYC/DDK-tagged

Cat.No. : CDK8-10H
Product Overview : Recombinant Human CDK8, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
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Species : Human
Source : HEK293
Tag : DDK&Myc
Description : The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
Molecular Mass : 53.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name CDK8 cyclin-dependent kinase 8 [ Homo sapiens (human) ]
Official Symbol CDK8
Synonyms cyclin-dependent kinase 8; K35; MGC126074; MGC126075; protein kinase K35; CDK8 protein kinase; cell division protein kinase 8; EC 2.7.11.22,EC 2.7.11.23; Protein kinase K35; CDK8; OTTHUMP00000018158; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8
Gene ID 1024
mRNA Refseq NM_001260
Protein Refseq NP_001251
MIM 603184
UniProt ID P49336
Chromosome Location 13q12
Pathway Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Developmental Biology; Fatty acid, triacylglycerol, and ketone body metabolism
Function ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein serine/threonine kinase activity; protein binding

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