Recombinant Human CDK3/CyclinE1, GST-tagged, Active
Cat.No. : | CDK3/CyclinE1-273H |
Product Overview : | Recombinant full-length human CDK3 and Cyclin E1 were co-expressed by baculovirus inSf9insect cells using an N-terminal GST tag on both proteins. |
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Species : | Human |
Source : | Sf9 Cells |
Tag : | GST |
Description : | CDK3/CyclinE1is a member of the cyclin-dependent protein kinase family and promotes entry into S phase, in part by activating members of the E2F family of transcription factors. CDK3 can also associate with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. The CDK3 gene has been mapped to chromosomal location of 17q22-qter, telomeric to the BRCA1 gene by somatic cell hybrids analysis. The presence of a single point mutation in the CDK3 gene from several Mus musculus strains commonly used in the laboratory has been reported. |
Molecular Weight : | ~60 kDa and CyclinE1 ~73 kDa. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name | CDK3 cyclin-dependent kinase 3 [ Homo sapiens ]CCNE1 cyclin E1 [ Homo sapiens ] |
Synonyms | CDK3; cyclin-dependent kinase 3; OTTHUMP00000206828; EC 2.7.11.22;Cell division protein kinase 3; CCNE1; cyclin E1; CCNE; cyclin E1; cyclin Es; cyclin Et; CCNE |
Gene ID | 1018898 |
mRNA Refseq | NM_001258NM_001238 |
Protein Refseq | NP_001249NP_001229 |
MIM | 123828123837 |
UniProt ID | Q00526P24864 |
Chromosome Location | 17q22-qter19q12 |
Pathway | Cell cycle; Pathways in cancer; Prostate cancer; Small cell lung cancer; p53 signaling pathway |
Function | ATP binding; cyclin-dependent protein kinase activity; nucleotide binding; protein binding; transferase activity; androgen receptor binding; protein complex binding; transcription coactivator activity |
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◆ Cell & Tissue Lysates | ||
CDK3-327HCL | Recombinant Human CDK3 cell lysate | +Inquiry |
Not For Human Consumption!
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