Recombinant Human CD83, Fc-tagged

Description :	Human CD83 is a 40-50 kDa member of the Siglec (or sialic-acid-binding immunoglobulin-like lectin) family of transmembrane proteins. CD83 is a primary marker for dendritic cells. It is also found on B cells, neutrophils, monocytes and macrophages. Except for dendritic cells, CD83 expression is often transient. CD83 binds to sialic acids on target cells. Membrane CD83 promotes T cell proliferation, particularly of CD8+ cytotoxic T cells. Soluble CD83 is immunosuppressive and blocks T cell activation. On monocytes, CD83 is suggested to drive monocytes into a fibrocyte phenotype. A lack of membrane-expressed CD83 leads to an unusual IL-4/ IL-10 producing CD4+ T cell phenotype.
Source :	CHO Cells
Species :	Human
Tag :	Fc
Form :	Lyophilized from 0.2μm-filtered solution in PBS.
Purity :	≥98% (SDS-PAGE)
Stability :	Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage :	Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.
Protein length :	20-131 a.a.

Gene Name	CD83 CD83 molecule [ Homo sapiens ]
Official Symbol	CD83
Synonyms	CD83; CD83 molecule; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily) , CD83 molecule; CD83 antigen; BL11; HB15; hCD83; B-cell activation protein; cell surface protein HB15; cell-surface glycoprotein; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily);
Gene ID	9308
mRNA Refseq	NM_001040280
Protein Refseq	NP_001035370
MIM	604534
UniProt ID	Q01151
Chromosome Location	6p23