Recombinant Human CCDC112 protein, HIS-tagged

• Cat.No.: DENND1B-015H
• Product Overview: Recombinant Human DENND1B fused with His tag at N-terminal was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091])
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 44.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: DENND1B DENN/MADD domain containing 1B [ Homo sapiens ]
• Official Symbol: DENND1B
• Synonyms: DENND1B; DENN/MADD domain containing 1B; C1orf218, chromosome 1 open reading frame 218 , FAM31B, family with sequence similarity 31, member B; DENN domain-containing protein 1B; FLJ20054; MGC27044; connecdenn 2; family with sequence similarity 31, member B; FAM31B; C1ORF18; C1orf218; RP11-53I24.2; FLJ21179; FLJ33888; MGC103810; DKFZp547O0715
• Gene ID: 163486
• mRNA Refseq: NM_001195215
• Protein Refseq: NP_001182144
• MIM: 613292
• UniProt ID: Q6P3S1