Recombinant Human CBLC, His-tagged

• Cat.No.: CBLC-10757H
• Product Overview: Recombinant Human CBLC protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: N-term-350a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: CBLC Cbl proto-oncogene, E3 ubiquitin protein ligase C [ Homo sapiens ]
• Official Symbol: CBLC
• Synonyms: CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas Br M (murine) ecotropic retroviral transforming sequence c , Cas Br M (murine) ectropic retroviral transforming sequence c; signal transduction protein CBL-C; CBL 3; CBL SL; RNF57; RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Cas-Br-M (murine) ectropic retroviral transforming sequence c; Cas-Br-M (murine) ecotropic retroviral transforming sequence c; CBL-3; CBL-SL
• Gene ID: 23624
• mRNA Refseq: NM_001130852
• Protein Refseq: NP_001124324
• MIM: 608453
• UniProt ID: Q9ULV8
• Chromosome Location: 19q13.2
• Pathway: Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem
• Function: SH3 domain binding; calcium ion binding; epidermal growth factor receptor binding; phosphotyrosine binding; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding