Recombinant Human CASR Protein (Y20-S1078 end), Flag, 10×His tagged

• Cat.No.: CASR-0502H
• Product Overview: Recombinant Human HA(signal peptide)-Flag-TEV-CaSR(Y20-S1078 end)-10His Protein was expressed in Insect cell.

Specification

• Description: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation.
• Source: Insect cell
• Species: Human
• Tag: His&Flag
• Form: Liquid
• Protein length: Y20-S1078 end
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 80%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: 20 mM HEPES pH 7.5, 150 mM NaCl, 0.005% GDN, 0.0005% CHS
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: CASR calcium-sensing receptor [ Homo sapiens (human) ]
• Official Symbol: CASR
• Synonyms: CASR; calcium-sensing receptor; HHC, HHC1, hypocalciuric hypercalcemia 1; extracellular calcium-sensing receptor; FHH; GPRC2A; NSHPT; severe neonatal hyperparathyroidism; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor; CAR; FIH; HHC; EIG8; HHC1; PCAR1; MGC138441
• Gene ID: 846
• mRNA Refseq: NM_000388
• Protein Refseq: NP_000379
• UniProt ID: P41180