Recombinant Human CARM1, Flag-tagged

• Cat.No.: CARM1-999H
• Product Overview: Recombinant Human EZH2(amino-acids 2-end), fused with N-terminal Flag tag, was expressed in a FreeStyle 293-F cells.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST&His
• Protein Length: 2-end a.a.
• Description: This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9.
• Form: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ug/ml Flag peptide, 20% glycerol and 3 mM DTT.
• Molecular Mass: 66 kDa
• Purity: Purity>70%
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Storage: >6 months at –80°C

Gene Information

• Gene Name: CARM1 coactivator-associated arginine methyltransferase 1 [ Homo sapiens (human) ]
• Official Symbol: CARM1
• Synonyms: CARM1; coactivator-associated arginine methyltransferase 1; PRMT4; EC 2.1.1.125; 3` partial; protein arginine N-methyltransferase 4; Histone-arginine methyltransferase CARM1; EC 2.1.1.-; Protein arginine N-methyltransferase 4; Coactivator-associated arginine methyltransferase 1
• Gene ID: 10498
• mRNA Refseq: NM_199141
• Protein Refseq: NP_954592
• MIM: 603934
• UniProt ID: Q86X55
• Chromosome Location: 19p13.2
• Pathway: Activation of gene expression by SREBF (SREBP); BMAL1:CLOCK,NPAS2 activates circadian gene expression; Coregulation of Androgen receptor activity
• Function: histone methyltransferase activity (H3-R17 specific); histone-arginine N-methyltransferase activity; protein homodimerization activity