Recombinant Human CARD8 cell lysate

• Cat.No.: CARD8-283HCL

Specification

• Species: Human
• Tag: Non
• Description: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: CARD8 caspase recruitment domain family, member 8 [ Homo sapiens ]
• Official Symbol: CARD8
• Synonyms: CARD8; caspase recruitment domain family, member 8; caspase recruitment domain-containing protein 8; CARDINAL; Dakar; KIAA0955; NDPP; TUCAN; apoptotic protein NDPP1; CARD inhibitor of NF-kappaB-activating ligands; tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine; DACAR; DAKAR; NDPP1; FLJ18119; FLJ18121; MGC57162; DKFZp779L0366
• Gene ID: 22900
• mRNA Refseq: NM_001184900
• Protein Refseq: NP_001171829
• MIM: 609051
• UniProt ID: Q9Y2G2
• Chromosome Location: 19q13.33
• Pathway: NOD-like receptor signaling pathway, organism-specific biosystem; NOD-like receptor signaling pathway, conserved biosystem
• Function: NACHT domain binding; cysteine-type endopeptidase activator activity involved in apoptotic process; protein binding; protein homodimerization activity