Description :	The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene.
Source :	HEK293 cells
Species :	Human
Tag :	Myc&DDK
Molecular Mass :	79.8 kDa
Purity :	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration :	>50 ug/mL as determined by microplate BCA method
Storage Buffer :	25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Name	CAPN2 calpain 2, (m/II) large subunit [ Homo sapiens (human) ]
Official Symbol	CAPN2
Synonyms	CAPN2; calpain 2, (m/II) large subunit; calpain-2 catalytic subunit; CANPL2; CANPml; mCANP; CANP 2; M-calpain; calpain M-type; millimolar-calpain; calpain-2 large subunit; calpain 2, large subunit; calpain large polypeptide L2; calpain, large polypeptide L2; calpain 2, large [catalytic] subunit; calcium-activated neutral proteinase 2; CANP2; FLJ39928
Gene ID	824
mRNA Refseq	NM_001748
Protein Refseq	NP_001739
MIM	114230
UniProt ID	P17655
Chromosome Location	1q41-q42
Pathway	Alzheimers Disease; ErbB1 downstream signaling; Protein processing in endoplasmic reticulum
Function	calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cysteine-type peptidase activity