Recombinant Human CAMK2D, GST-tagged, Active

• Cat.No.: CAMK2D-266H
• Product Overview: Recombinant full-length human CAMK2delta was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 77 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: CAMK2D is a serine/threonine protein kinase that is a member of the type II multifunctional Ca2+/calmodulin-dependent protein kinase family. CAMK2D is abundantly present in human cardiac and skeletal muscle and its levels are increased in the heart of patients suffering from cardiomyopathy . In cardiomyocytes, stimulation of beta-1-adrenergic receptor leads to induction of apoptosis, an effect that is mediated by activation of CAMK2D in a PKA-independent manner. In addition, expression studies have revealed the downregulation of CAMK2D in human tumor cells.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CAMK2D calcium/calmodulin-dependent protein kinase II delta [ Homo sapiens ]
• Synonyms: CAMK2D; calcium/calmodulin-dependent protein kinase II delta; CAMKD; MGC44911; DKFZp686I2288; DKFZp686G23119; OTTHUMP00000163830; CaMK-II delta subunit; CaM-kinase II delta chain; CaM kinase II delta subunit; calcium/calmodulin-dependent protein kinase type II delta chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; EC 2.7.11.17; OTTHUMP00000163829; CaM kinase II subunit delta; CaMK-II subunit delta
• Gene ID: 817
• mRNA Refseq: NM_001221
• Protein Refseq: NP_001212
• MIM: 607708
• UniProt ID: Q13557
• Chromosome Location: 4q26
• Pathway: Calcium signaling pathway; ErbB signaling pathway; Glioma; GnRH signaling pathway; Long-term potentiation; Melanogenesis; Neurotrophin signaling pathway; Olfactory transduction; Wnt signaling pathway
• Function: ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; nucleotide binding; transferase activity