Recombinant Human CAMK2B Protein (A2-Q666), Tag Free

• Cat.No.: CAMK2B-0173H
• Product Overview: Recombinant Human GG-CAMK2β(A2-Q666 end) Protein was expressed in Insect cell.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Non
• Protein Length: A2-Q666
• Description: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
• Form: Liquid
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: CAMK2B calcium/calmodulin-dependent protein kinase II beta [ Homo sapiens (human) ]
• Official Symbol: CAMK2B
• Synonyms: CAMK2B; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin dependent protein kinase (CaM kinase) II beta, CAMKB; calcium/calmodulin-dependent protein kinase type II subunit beta; calcium/calmodulin dependent protein kinase type II beta chain; CaM kinase II beta subunit; CaM kinase II beta chain; CAM2; CAMK2; proline rich calmodulin dependent protein kinase; caMK-II subunit beta; CaM-kinase II beta chain; proline rich calmodulin-dependent protein kinase; CAMKB; MGC29528
• Gene ID: 816
• mRNA Refseq: NM_001220
• Protein Refseq: NP_001211
• MIM: 607707
• UniProt ID: Q13554