CAMK2B
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Official Full Name
calcium/calmodulin-dependent protein kinase II, beta -
Overview
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. -
Synonyms
CAMK2B;calcium/calmodulin-dependent protein kinase II, beta;Camk2d;calcium/calmodulin-dependent protein kinase type II subunit beta;CaMK II;caMK-II subunit beta;caM kinase II subunit beta;calcium/calmodulin-dependent protein kinase II, delta
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Insect Cells
- Wheat Germ
- Sf9 Cells
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- Sf21 Cells
- GST
- His
- Non
- DDK
- Myc
Involved Pathway
CAMK2B involved in several pathways and played different roles in them. We selected most pathways CAMK2B participated on our site, such as ErbB signaling pathway,Calcium signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMK2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oocyte meiosis | PPP2R5EB,YWHAE,CDC25C,YWHAZ,SLKA,YWHAB,CALM1A,PPP1CBL,ADCY2B,Adcy4 |
| Melanogenesis | FZD7B,CALM2A,FZD7,CALM4,GNA15.1,MAPK3,WNT4A,WNT16,WNT1,KIT |
| cAMP signaling pathway | PIK3CD,NPY,ATP1A3,GRIN3B,SLC9A1,CREB3L2,ATP1B1,ACOX3,CALM2,LIPE |
| Calcium signaling pathway | ORAI2,LHCGR,TNNC1A,HTR2B,P2RX6,PRKCB,STIM2,CHRM1,EDNRB2,DRD1A |
| Long-term potentiation | NRAS,GRIN2D,MAP2K1,RAP1B,ITPR3,CALM4,PPP1CB,PRKCB,PLCB4,CAMK4 |
| Aldosterone synthesis and secretion | PDE2A,CYP11A1,CREB3L1,ADCY9,CREB3,CREB3L4,PRKD1,ATF6B,CACNA1G,KCNK9 |
| Circadian entrainment | PLCB1,PRKCB,GNAS,GNAO1,GRIN1,GRIA2,PRKCA,KCNJ9,PER3,RPS6KA5 |
| GnRH signaling pathway | MAP2K4A,GNRHR2,PRKCA,PLD1,PRKCD,MAPK11,MAPK9,PLD1A,GNA11,MAP2K6 |
| Dopaminergic synapse | CALML5,GNB3,MAPK11,PRKCB,KCNJ5,CREB5,MAPK12,PRKCA,CAMK2A,DRD1A |
Protein Function
CAMK2B has several biochemical functions, for example, ATP binding,actin binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMK2B itself. We selected most functions CAMK2B had, and list some proteins which have the same functions with CAMK2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin-dependent protein kinase activity | PNCK,CAMK2B1,DCX,CAMKK2,CAMK2D,MKNK2A,MAPKAPK2A,MKNK2B,CAMK1,SLC14A2 |
| protein homodimerization activity | PDCD10,Fzd4,PDGFC,HSD17B4,STK10,SLC51A,TOP2A,SLC22A1,GRHPR,UGT1A1 |
| actin binding | SPTBN1,WIPF2B,PTK2,CAPZA1,HIP1,SCINLB,PLECA,GMFG,PAWR,PARVB |
| calmodulin binding | MYO9B,NOS2,CAMKVB,SNTA1,MYH1B,MYO10,CALD1B,MYH11,KCNN1A,SPTAN1 |
| ATP binding | PRPS2,DNAJA4,ROCK1,SYK,AKT2L,DDX50,CDKL3,MAPK3,MAPK10,HYOU1 |
| protein binding | MPZL1L,SFRP5,SLA2,CHCHD1,ST8SIA5,MARCKSL1,MED23,LDLR,UBQLN2,CYFIP1 |
Interacting Protein
CAMK2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMK2B here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMK2B.
b3kwq7_human;146664;ACOT7;RBFOX2;KRTAP10-11;RAP2B;RPL11
Resources
Research Area
Calcium-binding Proteins and Related MoleculesIntracellular Kinases in the Akt Pathway
CaM Kinases
Negative Regulators of the Jak/STAT Pathway
Positive Regulators of the Jak/STAT Pathway
Wnt Intracellular Signaling
Intracellular Signaling Molecules in Angiogenesis
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References
