Recombinant Human CALU, His-tagged

• Cat.No.: CALU-26206TH
• Product Overview: Recombinant full length Human Calumenin with a N terminal His tag. 317 amino acids with a predicted MWt 37.2 kDa including tag.

Specification

• Description: The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Protein length: 296 amino acids
• Conjugation: HIS
• Molecular Weight: 37.200kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:10% Glycerol, 0.32% Tris HCl
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MKPTEKKDRV HHEPQLSDKV HNDAQSFDYD HDAFLGAEEA KTFDQLTPEE SKERLGKIVS KIDGDKDGFV TVDELKDWIK FAQKRWIYED VERQWKGHDL NEDGLVSWEE YKNATYGYVL DDPDPDDGFN YKQMMVRDER RFKMADKDGD LIATKEEFTA FLHPEEYDYM KDIVVQETME DIDKNADGFI DLEEYIGDMY SHDGNTDEPE WVKTEREQFV EFRDKNRDGK MDKEETKDWI LPSDYDHAEA EARHLVYESD QNKDGKLTKE EIVDKYDLFV GSQATDFGEA LVRHDEF.
• Sequence Similarities: Belongs to the CREC family.Contains 6 EF-hand domains.

Gene Information

• Gene Name: CALU calumenin [ Homo sapiens ]
• Official Symbol: CALU
• Synonyms: CALU; calumenin
• Gene ID: 813
• mRNA Refseq: NM_001130674
• Protein Refseq: NP_001124146
• MIM: 603420
• Uniprot ID: O43852
• Chromosome Location: 7q32
• Pathway: Hemostasis, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Platelet degranulation, organism-specific biosystem; Response to elevated platelet cytosolic Ca2+, organism-specific biosystem
• Function: calcium ion binding; protein binding