Recombinant Human calsequestrin 1 Protein, Tag Free

• Cat.No.: CASQ1-185H
• Product Overview: Recombinant human CASQ1 protein (P31415) (Gln 35-Asp 396) without tag was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Protein Length: 35-396aa
• Description: This gene encodes the skeletal muscle specific member of the calsequestrin protein family. Calsequestrin functions as a luminal sarcoplasmic reticulum calcium sensor in both cardiac and skeletal muscle cells. This protein, also known as calmitine, functions as a calcium regulator in the mitochondria of skeletal muscle. This protein is absent in patients with Duchenne and Becker types of muscular dystrophy. Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca (2+) ions. Regulates the release of lumenal Ca (2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca (2+) entry (SOCE) activity.
• Tag: Non
• Molecular Mass: 42 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: CASQ1 calsequestrin 1 [ Homo sapiens (human) ]
• Official Symbol: CASQ1
• Synonyms: CASQ1; calsequestrin 1 (fast-twitch, skeletal muscle); CASQ; calsequestrin-1; calmitine; calsequestrin 1; fast twitch; skeletal muscle; PDIB1; calmitin; calsequestrin, skeletal muscle isoform
• Gene ID: 844
• mRNA Refseq: NM_001231
• Protein Refseq: NP_001222
• MIM: 114250
• UniProt ID: P31415