Recombinant Human Calcitonin-Related Polypeptide Alpha, His-tagged

• Cat.No.: CALCA-047H
• Product Overview: Recombinant Human CALCAis a single, non-glycosylated, polypeptide chain containing 114 amino acidsfragment (3-116) and an amino-terminal hexahistidine tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 3-116 a.a.
• Description: CALCA is a 32-amino acid linear polypeptidehormone that is produced in humans primarily by the parafollicular cells(also known as C-cells) of the thyroid, and in many other animals in theultimobranchial body. It acts to reduce blood calcium (Ca2+), opposing theeffects of parathyroid hormone (PTH). CALCAhas been found in fish, reptiles, birds, and mammals. Its importance inhumans has not been as well established as its importance in other animals,as its function is usually not significant in the regulation of normalcalcium homeostasis. It belongs to calcitonin-like protein family.
• Form: Sterile filteredliquid in PBS + 50% glycerol.
• Molecular Weight: 17.13 kDa
• Purity: > 95.0% asdetermined by RP-HPLC and SDS-PAGE analyses.
• Endotoxin Level: < 0.1 ng/µg ofPCT
• Storage: Stable for 4 weeksat 2-4°C or in working aliquots at -20°C for longer storage. Avoid repeatedfreeze-thaw cycles.
• OfficialSymbol: CALCA

Gene Information

• Gene Name: CALCA calcitonin-relatedpolypeptide alpha [ Homo sapiens ]
• Synonyms: CALCA;calcitonin-related polypeptide alpha; CT; KC; CGRP; CALC1; CGRP1; CGRP-I;MGC126648; calcitonin; katacalcin; calcitonin 1; alpha-type CGRP; Alpha-typeCGRP; OTTHUMP00000216318; OTTHUMP00000216319; OTTHUMP00000216320;OTTHUMP00000216321; calcitonin gene-related peptide I; calcitoningene-related peptide I
• Gene ID: 796
• mRNA Refseq: NM_001741
• Protein Refseq: NP_001732
• MIM: 114130
• UniProt ID: P01258
• Chromosome Location: 11p15.2
• Pathway: Amyloids;Calcitonin-like ligand receptors; Class B/2 (Secretin family receptors); Galpha (s) signalling events; GPCR downstream signaling; GPCR ligand binding;Myometrial Relaxation and Contraction Pathways; Signal Transduction;Signaling by GPCR
• Function: calcitonin receptorbinding; hormone activity; receptor binding