Recombinant Human CACNA1B Protein, His-tagged

• Cat.No.: CACNA1B-351H
• Product Overview: Recombinant Human CACNA1B Protein (Met1-Asp132) with N-His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Met1-Asp132
• Description: The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 18.0 kDa
  Accurate Molecular Mass: 18 kDa
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit [ Homo sapiens (human) ]
• Official Symbol: CACNA1B
• Synonyms: CACNA1B; calcium channel, voltage-dependent, N type, alpha 1B subunit; CACNL1A5; voltage-dependent N-type calcium channel subunit alpha-1B; CACNN; Cav2.2; calcium channel, N type; brain calcium channel III; Cav2.2 voltage-gated Ca2+ channel; calcium channel alpha12.2 subunit; calcium channel, L type, alpha-1 polypeptide; voltage-gated calcium channel alpha subunit Cav2.2; voltage-gated calcium channel subunit alpha Cav2.2; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, alpha 1B subunit, N type; BIII
• Gene ID: 774
• mRNA Refseq: NM_000718
• Protein Refseq: NP_000709
• MIM: 601012
• UniProt ID: Q00975