Recombinant Human C1QA protein, His&Myc-tagged

• Cat.No.: C1QA-2607H
• Product Overview: Recombinant Human C1QA protein(P02745)(23-245aa), fused to N-terminal His tag and C-terminal Myc tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His&Myc
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 30.7 kDa
• Protein length: 23-245aa
• AA Sequence: EDLCRAPDGKKGEAGRPGRRGRPGL KGEQGEPGAPGIRTGIQGLKGDQGE PGPSGNPGKVGYPGPSGPLGARGIP GIKGTKGSPGNIKDQPRPAFSAIRR NPPMGGNVVIFDTVITNQEEPYQNH SGRFVCTVPGYYYFTFQVLSQWEIC LSIVSSSRGQVRRSLGFCDTTNKGL FQVVSGGMVLQLQQGDQVWVEKDPK KGHIYQGSEADSVFSGFLIFPSA
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: C1QA complement component 1, q subcomponent, A chain [ Homo sapiens ]
• Official Symbol: C1QA
• Synonyms: C1QA; complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide; complement C1q subcomponent subunit A; complement component C1q, A chain
• Gene ID: 712
• mRNA Refseq: NM_015991
• Protein Refseq: NP_057075
• MIM: 120550
• UniProt ID: P02745

Reviews

01/23/2022

Excellent quality, fast delivery.

03/01/2021

Reliable in experiments, quality.

02/09/2020

Product met all requirements.

Q&As

What role does C1QA play in the clearance of apoptotic cells?

It plays a role in recognizing and promoting the removal of apoptotic cells.

What therapeutic strategies are being explored involving C1QA modulation?

Strategies are being explored to modulate C1QA activity in conditions like lupus and rheumatoid arthritis.

Are there known genetic mutations in C1QA associated with specific health conditions?

Genetic deficiencies in C1QA are linked to increased susceptibility to infections and autoimmune conditions.

In which immune responses is C1QA critically involved?

C1QA is involved in immune responses against pathogens and in the clearance of immune complexes.

How is C1QA implicated in autoimmune diseases?

Dysregulation of C1QA can contribute to impaired clearance of immune complexes, leading to autoimmune diseases.

How does C1QA contribute to the activation of the complement system?

It binds to antibodies or C-reactive protein on pathogen surfaces, activating C1r and C1s in the C1 complex.

What is the primary function of C1QA in the immune system?

C1QA is a vital component of the C1 complex, initiating the classical complement pathway.