Recombinant Human C-Ros Oncogene 1, Receptor Tyrosine Kinase, GST-tagged

• Cat.No.: ROS1-1091H
• Product Overview: Recombinant human ROS1 (1883-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 1883-end a.a.
• Description: ROS1 is a proto-oncogene and member of the sevenless subfamily of tyrosine kinase insulin receptor genes. ROS1 is highly-expressed in a variety of tumor cell lines and functions as a growth or differentiation factor receptor. The FIG gene can fuse with the ROS1 gene in glioblastoma cell lines. The resulting ROS1 fusion protein is a constitutively activated tyrosine kinase.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 82 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol.
• Specific Activity: 640 nmol/min/mg
• Purity: > 75 %
• Concentration: 0.1 ug/ul
• Sequences: 1883-edd
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: ROS1 c-ros oncogene 1 , receptor tyrosine kinase [ Homo sapiens ]
• Official Symbol: ROS1
• Synonyms: ROS1; c-ros oncogene 1, receptor tyrosine kinase; ROS; MCF3; c-ros-1; EC 2.7.10.1; proto-oncogene tyrosine-protein kinase ROS; OTTHUMP00000017814; OTTHUMP00000017815; proto-oncogene c-Ros-1; v-ros UR2 sarcoma virus oncogene homolog 1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1 (avian); Proto-oncogene tyrosine-protein kinase ROS; Proto-oncogene c-Ros-1
• Gene ID: 6098
• mRNA Refseq: NM_002944
• Protein Refseq: NP_002935
• MIM: 165020
• UniProt ID: P08922
• Chromosome Location: 6q21-q22
• Function: ATP binding; nucleotide binding; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity