Recombinant Human BRIP1, His-tagged

• Cat.No.: BRIP1-10291H
• Product Overview: Recombinant Human BRIP1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-342a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: BRIP1 BRCA1 interacting protein C-terminal helicase 1 [ Homo sapiens ]
• Official Symbol: BRIP1
• Synonyms: BRIP1; BRCA1 interacting protein C-terminal helicase 1; Fanconi anemia group J protein; BACH1; BRCA1/BRCA2 associated helicase 1; FANCJ; OF; ATP-dependent RNA helicase BRIP1; BRCA1/BRCA2-associated helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; FLJ90232; MGC126521; MGC126523
• Gene ID: 83990
• mRNA Refseq: NM_032043
• Protein Refseq: NP_114432
• MIM: 605882
• UniProt ID: Q9BX63
• Chromosome Location: 17q22.2
• Pathway: DNA Repair, organism-specific biosystem; Double-Strand Break Repair, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Homologous DNA pairing and strand exchange, organism-specific biosystem; Homologous Recombination Repair, organism-specific biosystem; Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystem
• Function: ATP binding; ATP-dependent DNA helicase activity; DNA binding; helicase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; nucleotide binding; protein binding