Recombinant Human BRAT1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: BRAT1-5239H
• Product Overview: C7orf27 MS Standard C13 and N15-labeled recombinant protein (NP_689956) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 88 kDa
• AA Sequence: MDPECAQLLPALCAVLVDPGQPVAD DTCLEKLLDWFKTVTEGESSVVLLQ EHPCLVELLSHVLKVQDLSSGVLSF SLRLAGTFAAQENCFQYLQQGELLP GLFGEPGPLGRATWAVPTVRSGWIQ GLRSLAQHPSALRFLADHGAVDTIF SLQGDSSLFVASAASQLLVHVLALS MRGGAEGQPCLPGGDWPACAQKIMD HVEESLCSAATPKVTQALNVLTTTF GRCQSPWTEALWVRLSPRVACLLER DPIPAAHSFVDLLLCVARSPVFSSS DGSLWETVARALSCLGPTHMGPLAL GILKLEHCPQALRTQAFQVLLQPLA CVLKATVQAPGPPGLLDGTADDATT VDTLLASKSSCAGLLCRTLAHLEEL QPLPQRPSPWPQASLLGATVTVLRL CDGSAAPASSVGGHLCGTLAGCVRV QRAALDFLGTLSQGTGPQELVTQAL AVLLECLESPGSSPTVLKKAFQATL RWLLSSPKTPGCSDLGPLIPQFLRE LFPVLQKRLCHPCWEVRDSALEFLT QLSRHWGGQADFRCALLASEVPQLA LQLLQDPESYVRASAVTAMGQLSSQ GLHAPTSPEHAEARQSLFLELLHIL SVDSEGFPRRAVMQVFTEWLRDGHA DAAQDTEQFVATVLQAASRDLDWEV RAQGLELALVFLGQTLGPPRTHCPY AVALPEVAPAQPLTEALRALCHVGL FDFAFCALFDCDRPVAQKSCDLLLF LRDKIASYSSLREARGSPNTASAEA TLPRWRAGEQAQPPGDQEPEAVLAM LRSLDLEGLRSTLAESSDHVEKSPQ SLLQDMLATGGFLQGDEADCYTRTR PLEQKLISEEDLAANDILDYKDDDD KV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: BRAT1 BRCA1-associated ATM activator 1 [ Homo sapiens (human) ]
• Official Symbol: BRAT1
• Synonyms: BRAT1; BRCA1-associated ATM activator 1; BAAT1, C7orf27, chromosome 7 open reading frame 27; BRCA1 associated protein required for ATM activation protein 1; MGC22916; HEAT repeat-containing protein C7orf27; BRCA1-associated protein required for ATM activation protein 1; BAAT1; RMFSL; C7orf27
• Gene ID: 221927
• mRNA Refseq: NM_152743
• Protein Refseq: NP_689956
• MIM: 614506
• UniProt ID: Q6PJG6