Recombinant Human/Bovine/Porcine GREM1 Protein

• Cat.No.: GREM1-19H
• Product Overview: Recombinant human/bovine/porcine Gremlin 1 protein without tag was expressed in E. coli.
  Animal-free (AOF) and carrier protein-free.
  Mass spectrometry: single species with expected mass.
  Analytical reversed-phase: single sharp peak.
  Recovery from stock vial: >95%

Specification

• Species: Human
• Source: E.coli
• Description: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Molecular Mass: 18 kDa
• Endotoxin: <0.005 EU/μg protein (below level of detection)
• Applications: Human pluripotent Stem cell maintenance; Mesoderm Differentiation
• Storage: Resuspend in 10mM HCl at >100 μg/mL, prepare single use aliquots, add carrier protein if desired and store frozen at -20 or -80 centigrade
• Storage Buffer: Lyophilized from acetonitrile, TFA

Gene Information

• Gene Name: GREM1 gremlin 1, DAN family BMP antagonist [ Homo sapiens (human) ]
• Official Symbol: GREM1
• Synonyms: GREM1; gremlin 1, DAN family BMP antagonist; DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1; gremlin-1; DAN domain family member 2; cell proliferation-inducing gene 2 protein; colorectal adenoma and carcinoma 1; cysteine knot superfamily 1, BMP antagonist 1; down-regulated in Mos-transformed cells protein; gremlin 1, cysteine knot superfamily, homolog; gremlin 1-like protein; hereditary mixed polyposis syndrome; increased in high glucose-2
• Gene ID: 26585
• mRNA Refseq: NM_013372
• Protein Refseq: NP_037504
• MIM: 603054
• UniProt ID: O60565