Recombinant Human BIRC7 Protein (M1-S298), His tagged
Cat.No. : | BIRC7-0093H |
Product Overview : | Recombinant Human 6His-TEV-(GG)-LIVIN(BIRC7) (M1-S298 end) Protein was expressed in E. coli. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | M1-S298 |
Description : | Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and MAP3K7/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. |
Form : | Liquid |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name | BIRC7 baculoviral IAP repeat containing 7 [ Homo sapiens (human) ] |
Official Symbol | BIRC7 |
Synonyms | BIRC7; baculoviral IAP repeat containing 7; baculoviral IAP repeat-containing protein 7; KIAP; kidney inhibitor of apoptosis protein; livin; livin inhibitor of apoptosis; melanoma inhibitor of apoptosis protein; ML IAP; mliap; RNF50; RING finger protein 50; LIVIN; MLIAP; ML-IAP; |
Gene ID | 79444 |
mRNA Refseq | NM_022161 |
Protein Refseq | NP_071444 |
MIM | 605737 |
UniProt ID | Q96CA5 |
◆ Recombinant Proteins | ||
BIRC7-0093H | Recombinant Human BIRC7 Protein (M1-S298), His tagged | +Inquiry |
BIRC7-232H | Recombinant Human BIRC7 Protein, GST-tagged | +Inquiry |
BIRC7-1036M | Recombinant Mouse BIRC7 Protein, His (Fc)-Avi-tagged | +Inquiry |
BIRC7-2569H | Recombinant Human BIRC7 protein, His-tagged | +Inquiry |
Birc7-1870M | Recombinant Mouse Birc7 Protein, Myc/DDK-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
BIRC7-8448HCL | Recombinant Human BIRC7 293 Cell Lysate | +Inquiry |
BIRC7-8447HCL | Recombinant Human BIRC7 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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